Creative biogene - A small hairpin RNA or short hairpin RNA (#shRNA) is a sequence of RNA that makes a tight hairpin turn that can be used to silence target gene expression
![Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response: Molecular Therapy - Nucleic Acids Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/asset/6a4a8e46-088b-4868-9340-25e3a66796a2/gr1.jpg)
Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response: Molecular Therapy - Nucleic Acids
![shRNA mechanism | short hairpin RNA | small hairpin RNA | Gene silencing technique | Gene knockdown - YouTube shRNA mechanism | short hairpin RNA | small hairpin RNA | Gene silencing technique | Gene knockdown - YouTube](https://i.ytimg.com/vi/GqCdTl7a0Mg/maxresdefault.jpg)
shRNA mechanism | short hairpin RNA | small hairpin RNA | Gene silencing technique | Gene knockdown - YouTube
![Frontiers | RISC-y Business: Limitations of Short Hairpin RNA-Mediated Gene Silencing in the Brain and a Discussion of CRISPR/Cas-Based Alternatives Frontiers | RISC-y Business: Limitations of Short Hairpin RNA-Mediated Gene Silencing in the Brain and a Discussion of CRISPR/Cas-Based Alternatives](https://www.frontiersin.org/files/Articles/914430/fnmol-15-914430-HTML-r2/image_m/fnmol-15-914430-g001.jpg)
Frontiers | RISC-y Business: Limitations of Short Hairpin RNA-Mediated Gene Silencing in the Brain and a Discussion of CRISPR/Cas-Based Alternatives
![Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA: Molecular Therapy - Nucleic Acids Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/6ca4dad5-7304-4a79-a99e-62cfe78549f1/gr1.jpg)
Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA: Molecular Therapy - Nucleic Acids
![Utility of Epstein–Barr virus-encoded small RNA promoters for driving the expression of fusion transcripts harboring short hairpin RNAs | Gene Therapy Utility of Epstein–Barr virus-encoded small RNA promoters for driving the expression of fusion transcripts harboring short hairpin RNAs | Gene Therapy](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsj.gt.3303055/MediaObjects/41434_2008_Article_BF3303055_Fig1_HTML.jpg)
Utility of Epstein–Barr virus-encoded small RNA promoters for driving the expression of fusion transcripts harboring short hairpin RNAs | Gene Therapy
![Rational design of hairpin RNA excited states reveals multi-step transitions | Nature Communications Rational design of hairpin RNA excited states reveals multi-step transitions | Nature Communications](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-022-29194-8/MediaObjects/41467_2022_29194_Fig1_HTML.png)
Rational design of hairpin RNA excited states reveals multi-step transitions | Nature Communications
![A direct comparison of strategies for combinatorial RNA interference | BMC Molecular Biology | Full Text A direct comparison of strategies for combinatorial RNA interference | BMC Molecular Biology | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2F1471-2199-11-77/MediaObjects/12867_2010_10233_Fig1_HTML.jpg)
A direct comparison of strategies for combinatorial RNA interference | BMC Molecular Biology | Full Text
![Adenovirus-based short hairpin RNA vectors containing an EGFP marker and mouse U6, human H1, or human U6 promoter | BioTechniques Adenovirus-based short hairpin RNA vectors containing an EGFP marker and mouse U6, human H1, or human U6 promoter | BioTechniques](https://www.future-science.com/cms/10.2144/05384RN01/asset/images/medium/figure1.gif)
Adenovirus-based short hairpin RNA vectors containing an EGFP marker and mouse U6, human H1, or human U6 promoter | BioTechniques
![Figure 1 from RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs | Semantic Scholar Figure 1 from RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/612e67aedfa34efffdb657ee0d2c26faf718d734/1-Figure1-1.png)